Center on Race and Social Problems

Adapted Cognitive/Affective Rehabilitation for Substance Misuse in Schizophrenia

Principal Investigator(s): 
September 1, 2012 to May 1, 2016
Funded by: 
National Institute on Drug Abuse

This study aims to take the first step in integrating, adapting, and preliminarily testing a cognitive remediation (cognitive enhancement therapy [CET]) and affect regulation (personal therapy [PT]) intervention for patients with schizophrenia, many of whom are minorities and living in impoverished conditions, who are abusing cannabis and/or alcohol.  Patients will be randomized to CET/PT plus treatment as usual (TAU) or TAU alone and treated for 18 months. Treatment adherence, attendance, and satisfaction data will be collected throughout the trial to assess the feasibility and acceptability, and outcome data will be used to assess initial efficacy.

A total of 32 substance abusing schizophrenia-50 percent of whom are racial minorities- have been enrolled and randomized to CET/PT (N = 22) or TAU (N = 10).  Individuals have begun treatment and preliminary efficacy testing.  Promising effects on cognition have been found for those receiving CET/PT.  Results about full treatment effects on functional outcomes are eagerly awaited.